If your health practitioner informs you to make use of additional than one patch, Keep to the Guidelines that come with the patches. Tend not to Permit the patches overlap on your skin.
If coadministration of CYP3A4 inhibitors with fentanyl is important, check patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose changes until finally stable drug effects are accomplished.
nafcillin will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a reduce in fentanyl plasma concentrations, lack of efficacy or, perhaps, growth of the withdrawal syndrome in a patient who has created physical dependence to fentanyl.
fentanyl iontophoretic transdermal system and fentanyl both of those improve sedation. Keep away from or Use Alternate Drug. Restrict use to patients for whom choice treatment options are inadequate
If coadministration of CYP3A4 inhibitors with fentanyl is critical, observe patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments till stable drug effects are accomplished.
Check Closely (1)levoketoconazole will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Restrict dosages and durations towards the minimum demanded. Observe intently for signs of respiratory depression and sedation.
fentanyl will raise the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Observe Carefully (1)enzalutamide will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to the reduce in fentanyl plasma concentrations, deficiency of efficacy or, probably, enhancement of a withdrawal syndrome in a individual who may have created physical dependence to fentanyl.
isavuconazonium sulfate will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
fentanyl, clemastine. Both increases toxicity on the other by pharmacodynamic synergism. Modify Therapy/Check Intently. Coadministration of fentanyl with anticholinergics could maximize risk for urinary retention and/or significant constipation, which can cause paralytic ileus.
Keep an eye on Intently (one)teclistamab will enhance the level or effect of fentanyl by altering metabolism. Use Warning/Keep track of. Teclistamab causes release of cytokines that may suppress exercise of CYP450 enzymes, leading to amplified exposure of CYP substrates.
Consider minimizing the dose with the delicate CYP3A4 substrate and fentanyl biverkningar observe for signs of toxicities of your coadministered delicate CYP3A substrate.
Take from the previous patch and fold it firmly in half Therefore the sticky side sticks to by itself. Set it back in its original packet and dispose of the packet as instructed by your pharmacist.